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Guide to Sjogren's Syndrome


Updated February 25, 2007

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Part 1 of 10 - What is Sjogren's Syndrome?

Sjogren's syndrome is an autoimmune disease, that is, a disease in which the immune system turns against the body's own cells. In Sjogren's syndrome, the immune system targets moisture-producing glands and causes dryness in the mouth and eyes. Other parts of the body can be affected as well, resulting in a wide range of possible symptoms.

  • Sjogren's Syndrome Screening Quiz
  • Moisture Producing Glands

    Normally, the immune system works to protect us from disease by destroying harmful invading organisms like viruses and bacteria. In the case of Sjogren's syndrome, disease-fighting cells attack the glands that produce tears and saliva. Damage to these glands keeps them from working properly and causes dry eyes and dry mouth. Your doctor may use these technical terms when talking to you about Sjogren's syndrome.

  • dry eyes are called keratoconjunctivitis sicca or KCS
  • dry mouth is called xerostomia
  • Other Glands

    The disease can affect other glands too, such as those in the:

  • stomach
  • pancreas
  • intestines
  • It can cause dryness in other places that need moisture, such as the:

  • nose
  • throat
  • airways
  • skin
  • Classification

    Sjogren's syndrome is one of over 100 rheumatic diseases. A rheumatic disease causes inflammation in:

  • joints
  • muscles
  • skin
  • other body tissue
  • Sjogren's syndrome is also considered a disorder of connective tissue, which is the framework of the body that supports organs and tissues (joints, muscles, and skin)

    Sjogren's syndrome is classified as either a primary or secondary disease.

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