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What Is Sjogren's Syndrome?

Dry Eyes And Dry Mouth Are The Primary Symptoms Of Sjogren's Syndrome

By Carol & Richard Eustice, About.com

Updated: May 24, 2006

About.com Health's Disease and Condition content is reviewed by the Medical Review Board

What is Sjogren's Syndrome?

Sjogren's syndrome is a condition which is often misdiagnosed or undiagnosed. Awareness and recognition of Sjogren's syndrome is important.

Experts believe 1 to 4 million people have the disease. Of this group, 90% are women. Sjogren's syndrome can occur at any age, but it usually is diagnosed after age 40 and can affect people of all races and ethnic backgrounds. Sjogren's syndrome is rare in children, but it can occur.

Many women have the disease but do not recognize the symptoms which are similar to those of other conditions including menopause.

  • Sjogren's Syndrome Screening Quiz
  • Symptoms Of Sjogren's Syndrome

    It has been suggested that many more people suffer with Sjogren's syndrome than have been diagnosed. Sjogren's syndrome is considered to be:

  • an autoimmune disease
  • a rheumatic disease
  • a connective tissue disorder
  • Abnormal production of autoantibodies in the blood which turn against various tissues in the body cause the disease. Inflammation in the glands of the body results from this abnormality.

    Sjogren's syndrome is characterized by:

  • dry mouth
  • dry eyes
  • hoarseness
  • vaginal dryness
  • skin dryness
  • chronic fatigue
  • A survey done by Bruskin/Goldring Research indicated that while three of four women over 35 years old suffer at least two of the possible symptoms associated with Sjogren's syndrome, over half of these women do not bring it to the attention of their physician, choosing instead to ignore the problem.

  • Guide to Sjogren's Syndrome
  • Guide to Dry Eyes
  • Guide to Dry Mouth
  • Primary Vs. Secondary Sjogren's Syndrome

    When only gland inflammation and resulting dry eyes and mouth are involved the disease is known as primary Sjogren's syndrome. There can also be extraglandular problems associated with Sjogren's syndrome which may include:

  • joint pain
  • Raynaud's phenomenon
  • lung inflammation
  • enlarged lymph nodes
  • vasculitis
  • kidney, nerve, or muscle disease
  • The disease is known as secondary Sjogren's syndrome when the gland inflammation exists in combination with another connective tissue disease or autoimmune disease such as:

  • lupus
  • scleroderma
  • rheumatoid arthritis
  • Lupus - Test Your Knowledge
  • Rheumatoid Arthritis - Test Your Knowledge
  • Guide to Scleroderma
  • Diagnosis of Sjogren's Syndrome

    The diagnosis of Sjogren's syndrome is based largely on the detection of dry eyes and mouth. Helpful diagnostic tools that serve in making the diagnosis include:

  • Schirmer's test for dry eyes
  • radiologic salivary scans
  • salivary flow testing
  • biopsy of salivary glands
  • blood tests
  • Treatment of Sjogren's Syndrome

    Treatment of Sjogren's syndrome is different for each person, depending on what parts of the body are affected. Although there is no cure for Sjogren's syndrome, mouthwashes, saliva substitutes, sprays, gels, and gum can relieve oral symptoms. Medications and drug treatment options for dry mouth associated with Sjogren's syndrome may include saliva and mucus stimulating drugs such as:

  • Salagen (Pilocarpine hydrochloride)
  • Evoxac (Cevimeline HCI)
  • Artificial tears and eye ointments can help relieve chronic dry eyes. Medications and drug treatment options for dry eye associated with Sjogren's syndrome may include:

  • Restasis (Cyclosporine Opthalmalic Emulsion)
  • Hydroxypropyl Cellulose (Eye Drops & Pellets)
  • Extraglandular problems such as joint pain or muscle pain involvement is often treated with NSAIDs (non-steroidal anti-inflammatory drugs). Lung, kidney, blood vessel, or nervous system problems may be treated with:

  • corticosteroids
  • DMARDs (disease-modifying anti-rheumatic drugs) or immunosuppressives
  • A person suffering with symptoms which may be due to Sjogren's syndrome must be aware of the need for medical assessment and the treatments available. Ignoring Sjogren's syndrome symptoms prolongs the suffering. Awareness leads to available help.

    Related Resources - Sjogren's Syndrome

  • Sjogren's Syndrome
  • Guide to Sjogren's Syndrome
  • Sjogren's Syndrome Screening Quiz
  • Sjogren's Syndrome Medications (Drugs to Treat Dryness)
  • The Sjogren's Syndrome Foundation
  • Source: April Is National Sjogren's Syndrome Awareness Month, PRNewswire; Sjogren's Syndrome, from MedicineNet.com; Questions and Answers About Sjogren's Syndrome, NIAMS, January 2001

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