Methotrexate was developed as a leukemia drug in the 1940s. The drug was considered experimental in the 1970s. It was approved by the U.S. Food and Drug Administration to treat rheumatoid arthritis in 1988.
Other Drugs Similar to Methotrexate:
The Rheumatrex Dose Pack contains blister cards containing the exact number of pills for a patient's weekly dose.
Brand name: Trexall is available in 5 mg, 7.5 mg, 10 mg, and 15 mg tablets.
Methotrexate is also available as an injectible formulation.
Conditions Treated by Methotrexate:
When You'll Notice Improvement:
How It Works:
Common Side Effects:
Who Should Not Take It:
People who are having surgery need to ask their doctor about temporarily stopping methotrexate. Your doctor will advise you.
People should not drink alcohol while taking methotrexate because of an increased risk of liver damage. Some doctors allow up to 2 alcoholic drinks per month.
What Else You Should Know:
Your doctor will use blood tests to monitor your liver and kidney function on a regular basis.
If you want to become pregnant, talk to your doctor. Methotrexate can cause birth defects and birth complications. You may be advised to use contraception until at least 3 months after you stop methotrexate.
Methotrexate. Indications. RXList.
Methotrexate (Rheumatrex). Cannon M.D., Michael. Fact Sheet. June 2006. American College of Rheumatology.
Arthritis Without Pain. Zashin M.D., Scott J.. Dallas, Texas: Sarah Allison Publishing Company, 2004.