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Guide to Juvenile Rheumatoid Arthritis (JRA)


Updated June 01, 2014

4 of 10

Part 4 of 10 - What Is Systemic Juvenile Rheumatoid Arthritis?

Systemic Juvenile Rheumatoid Arthritis

Besides joint swelling, the systemic form of juvenile rheumatoid arthritis is characterized by fever and a light skin rash, and may also affect internal organs such as the:

  • heart
  • liver
  • spleen
  • lymph nodes

Doctors sometimes call the systemic form of juvenile rheumatoid arthritis "Still's disease".


Almost all children with this type of juvenile rheumatoid arthritis test negative for both rheumatoid factor (RF) and antinuclear antibody (ANA).


The systemic form affects 20 percent of all children with juvenile rheumatoid arthritis. A small percentage of these children develop arthritis in many joints and can have severe arthritis that continues into adulthood.

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