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Guide to Juvenile Rheumatoid Arthritis (JRA)

By Carol & Richard Eustice, About.com

Updated: February 26, 2007

About.com Health's Disease and Condition content is reviewed by Kate Grossman, MD

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Part 10 of 10 - What Research is Being Conducted for JRA?

Registry

Scientists are investigating the possible causes of JRA. Researchers suspect that both genetic and environmental factors are involved in development of the disease and they are studying these factors in detail. To help explore the role of genetics, NIAMS has established a research registry for families in which two or more siblings have JRA. NIAMS also funds a Multipurpose Arthritis and Musculoskeletal Diseases Center (MAMDC) that specializes in research on pediatric rheumatic diseases including JRA.

The research registry for JRA is located at Children's Hospital Medical Center at the University of Cincinnati College of Medicine in Ohio. The registry, established in 1994, continues to list new cases as well as be maintained and systematically updated. The focus of the registry is on families whose brothers and sisters have JRA, with emphasis on genetic susceptibility in those affected families.

Other Research

Researchers are continuing to try to improve existing treatments and find new medicines that will work better with fewer side effects. For example, researchers are studying the long-term effects of the use of methotrexate in children. In addition, the Food and Drug Administration's "Pediatric Rule" requires manufacturers of new drugs and biologic agents, such as etanercept, that will be commonly used for children to provide specific information about safe pediatric use.

  • Juvenile Arthritis Research
  • Source: NIH Publication No. 01-4942 (edited)

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