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What Is Hyalgan?

A Hyaluronate Used in Viscosupplementation


Updated June 27, 2014

Joints of mixed race man's knee
Blend Images - John Lund/Brand X Pictures/Getty Images

Definition: Hyalgan is a solution of sodium hyaluronate. Hyalgan is one of the hyaluronates used in viscosupplementation. With viscosupplementation, hyalgan is injected directly into the knee joint to restore the cushioning and lubricating properties of normal joint fluid.

Hyalgan is used to relieve knee pain due to osteoarthritis, for those who failed to respond to simple painkillers, exercise or physical therapy.

Use for other joints is being investigated.

Facts About Hyalgan Injections:

  • Viscosupplementation has been studied for osteoarthritis treatment since the 1970s.
  • Hyalgan was FDA approved on 05/28/97.
  • Hyalgan injections are typically given once a week, one week apart, for a total of five injections. Some may benefit with only three.
  • Hyalgan was the first FDA approved hyaluronan therapy.
  • Hyalgan is considered a treatment or therapy, not a drug.

Also Known As: viscosupplementation, joint fluid therapy, hyaluronan injections, hyaluronate injections, joint fluid prosthesis, intra-articular knee injections

Common Misspellings: hyalgen, hyalgin, hyalgon, hyalgun, hialgan, hyalgann

Examples: The doctor recommended Hyalgan injections to help the osteoarthritis in my knee. Hyalgan is a type of intra-articular knee injection.


CDRH Consumer Information Hyalgan, Center for Devices and Radiological Health, July 2, 2002

Patient Information Hyalgan, Sanofi-Aventis, hyalgan.com.

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