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Is Arthritis Hereditary?

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Updated November 14, 2012

Question: Is Arthritis Hereditary?
If you have arthritis and you are a parent, it's without question your biggest worry -- will your children get arthritis too? Is arthritis hereditary? Because the hereditary aspect of arthritis is concerning -- should your children be tested?
Answer:

Family History and Genetics Are Arthritis Risk Factors

Certain risk factors increase the chance of developing arthritis. Genetics and family history are among the risk factors. Researchers have associated specific genes with certain types of arthritis, such as HLA-B27 and HLA-DR4.

Should Your Children Be Tested?

Since there are blood tests that help diagnose arthritis, parents often wonder if their children could be tested for arthritis -- at least to know what the future may hold. When asked how useful it would be to obtain lab work on the children of adults with arthritis, rheumatologist Scott J. Zashin, MD, said, "I do not recommend testing the blood of children without clinical symptoms whose parents have arthritis. These children are more likely to test positive for rheumatoid factor, ANA, and HLA-B27 and never develop the rheumatologic condition. Typically, no more than 10% of children from a parent with arthritis will develop a similar problem. On the other hand, if a child presents with the signs and symptoms of a chronic arthritis such as rheumatoid arthritis, lupus, or ankylosing spondylitis, then it is quite reasonable to obtain the appropriate lab work."

Bottom Line

Only test children if they are showing signs and symptoms of arthritis. Don't ignore arthritis warning signs but at the same time, don't impose your fears onto your children.

Dr. Zashin is clinical assistant professor at University of Texas Southwestern Medical School and an attending physician at Presbyterian Hospitals of Dallas and Plano. Dr. Zashin is author of Arthritis Without Pain - The Miracle Of TNF Blockers. The book is useful for anyone on one of the biologic drugs or considering the biologic drugs.

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