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Do blood tests monitor the effectiveness and toxicity of arthritis treatments?

By , About.com Guide

Updated August 14, 2007

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Question: Do blood tests monitor the effectiveness and toxicity of arthritis treatments?
Are laboratory tests routinely ordered to monitor the effectiveness of arthritis treatments? Are laboratory tests ordered which can detect side effects or problems which may be occurring while using a specific medication or treatment? Is it important for the patient to understand each test and follow their own results or should they depend on their doctor to notify them of any abnormalities or alarming results?
Answer: Monitoring the blood work of patients is an important part of the medical care for arthritis patients. Many of the medications used may increase the risk of liver, kidney and blood abnormalities. Fortunately, these problems are uncommon, but when they occur, can be very serious. As a result, doctors will periodically obtain blood work to help pick up problems before they become apparent clinically.

Lets take two common medications used to treat arthritis. The first is ibuprofen. Ibuprofen is considered a nonsteroidal anti-inflammatory drug or NSAID. While rare, these types of medications have been associated with kidney and liver failure. Monitoring the blood for these abnormalities typically picks up the problem early so the medication can be discontinued without any long term problems. In addition, the finding of a low red blood count or anemia can alert your doctors to the possibility that you may be developing a bleeding ulcer.

Methotrexate, a common rheumatoid arthritis (RA) medication, can be associated with liver damage and blood abnormalities such as a low white blood count. If the white blood count gets too low, it can increase the risk of infection.

In addition to monitoring blood for toxicity, rheumatologists will also typically order blood tests such as a sedimentation rate and C-reactive protein in RA patients to assess their response to treatment and a sedimentation rate and double stranded DNA in lupus patients.

Finally, make sure you hear back regarding your blood results. Doctors are seeing many patients these days and it is important to know that your results were reviewed!

Answers provided by Scott J. Zashin, M.D., clinical assistant professor at University of Texas Southwestern Medical School, Division of Rheumatology, in Dallas, Texas. Dr. Zashin is also an attending physician at Presbyterian Hospitals of Dallas and Plano. He is a fellow of the American College of Physicians and the American College of Rheumatology and a member of the American Medical Association. Dr. Zashin is author of Arthritis Without Pain - The Miracle of Anti-TNF Blockers. The book is useful for anyone on one of the biologic drugs (Enbrel, Remicade, Humira) or considering the biologic drugs. Read our review of the book.

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