What Are Antibodies?

Definition: Antibodies are proteins made by a B-cell which can recognize and attach to specific sites on antigens to block their effect. Studying this ability to target and bind to other molecules holds promise for researchers.

NIAID explains, "any substance capable of triggering an immune response is called an antigen. Each B cell is programmed to make one specific antibody. When a B cell encounters its triggering antigen (along with collaborating T cells and accessory cells), it gives rise to many large plasma cells. Every plasma cell is essentially a factory for producing antibodies."

According to NIAID, a given antibody matches an antigen much as a key matches a lock. The fit varies:

sometimes it's very precise

sometimes it's little better than that of a skeleton key

To some degree, however, the antibody interlocks with the antigen and thereby marks it for destruction.

NIAID states, "antibodies belong to a family of large molecules known as immunoglobulins. Immunoglobulins are proteins, made up of chains of polypeptides, strings of the basic units known as amino acids.

Each antibody has two identical heavy polypeptide chains and two identical light chains, shaped to form a Y. The sections that make up the tips of the Y's arms vary greatly from one antibody to another, creating a pocket uniquely shaped to enfold a specific antigen."

Related Explanations Of Antibodies

What The Heck Is An Antibody?

What Is A Monoclonal Antibody?

Understanding The Immune System

_{Source: NIH Pub 03-5423}

Common Misspellings: anitbodies