Question: Why do rheumatoid nodules develop and what do they signify?
Answer: As part of the rheumatoid process, firm, non-tender, subcutaneous nodules develop in about 25% of rheumatoid arthritis patients. These are commonly found at pressure points like the elbow, back of the forearm, and metacarpophalangeal joint. Nodules usually occur in chronic active cases of rheumatoid arthritis, and are commonly associated with more joint deformity and serious extra-articular manifestations including lungs, eyes, and blood vessels. Nodules may vary in size during the course of the disease process. (Answer provided by the late Dr. Raymond Federman, aka Dr. Bones, who passed away on September 2, 2003. The care of his patients even in retirement was always his joy.)
