Comparison: Celebrex And Vioxx
| PRECAUTIONS/WARNINGS | Celebrex | Vioxx |
| People with moderate liver disease can have twice as much Celebrex in blood than normal. May require reduced dosage. | People with moderate liver disease require reduced dosages. | |
| Effects in people with severe kidney or liver disease is not known. | Effect in people with severe liver failure is unknown. | |
| People with kidney function abnormalities have about 40% less Celebrex in blood than normal. | Should not be used in people with severe kidney disease. | |
| Should not be given to people who have experienced aspirin triad (rhinitis, nasal polyps, bronchospasm in asthmatics after taking aspirin). | Should not be given to people who have experienced aspirin triad (rhinitis, nasal polyps, bronchospasm in asthmatics after taking aspirin). | |
| Should be used with extreme caution in people who have had previous gastrointestinal or stomach ulcers, hepatitis, or liver cirrhosis. | Should be used with extreme caution in people who have had previous gastrointestinal or stomach ulcers, hepatitis, or liver cirrhosis. | |
| Should not be taken in late pregnancy. | Use of Vioxx in pregnant women has not been studied conclusively. Rat studies showed it not to be harmful to fetuses at high dosages, but rabbit studies showed it to be harmful to fetuses. | |
| Seniors should start with lowest possible dose. | Seniors can take Vioxx without special precautions, aiming for lowest dose possible. | |
| African-Americans absorb about 40% more Celebrex than Caucasians. | African-Americans and Hispanics absorb 10-15% more Vioxx than Caucasians. | |
| Should not be taken by people with sulfa sensitivity or allergy. |
