Comparison: Celebrex And Vioxx
| DRUG INTERACTIONS | Celebrex | Vioxx |
| Combination of Celebrex and an aluminum and magnesium antacid reduces the amount of drug absorbed. Allow 1-2 hours between. | Combination of Vioxx and an aluminum and magnesium antacid reduces the amount of drug absorbed. Allow 1-2 hours between. | |
| Fluconazole (anti-fungal) can raise blood levels of Celebrex and increase potential side effects. | Rifampin (tuberculosis drug) decreases the concentration of Vioxx in the body by 50%, may decrease effectiveness. | |
| Increases lithium (anti-psychotic) levels approximately 17% in people receiving both drugs. | Can increase lithium levels. Should be monitored carefully. | |
| Can reduce blood pressure lowering effect of ACE inhibitors and diuretics. | Can reduce effect of loop diuretics and thiazide-type diuretics. | |
| Concomitant use with aspirin or other NSAIDS raise risk of stomach ulcers. | High doses of cimetidine (tagamet) can increase amount of Vioxx in blood. | |
| No significant effect on methotrexate in people using both drugs. | Vioxx can increase concentration of methotrexate in blood by 25% and may increase side effects. |
