Arthrotec: Arthritis Treatment Combines An NSAID With Ulcer Protection

What Is Arthrotec?

Arthrotec is the first arthritis therapy which combines a NSAID (nonsteroidal anti-inflammatory drug) with protection against ulcers.

The formulation of Arthrotec consists of an enteric-coated core which contains either 50 or 75 mg. of diclofenac sodium and an outer layer containing 200 mcg. of misoprostol.

In worldwide clinical trials, Arthrotec showed a 65 to 80 percent lower incidence of such ulcers when compared to other commonly used NSAIDs.

NSAIDs

NSAIDs (non-steroidal anti-inflammatory drugs) effectively inhibit prostaglandins, which are naturally-occurring substances involved in the inflammatory process. Prostaglandins also serve to protect the mucosal lining of the stomach and duodenum. Chronic NSAID use can lead to ulcers as the prostaglandin levels in the stomach decrease.

The misoprostol portion of Arthrotec helps to protect the mucosal lining by reducing acid production, stimulating secretion of protective mucous and bicarbonate, and directing adequate blood flow.

Ulcer Risks

Studies have shown that about 25 percent of arthritis patients who chronically use NSAIDs can develop ulcers. All NSAID users have three times the risk of developing ulcers or gastrointestinal complications over non-NSAID users. Certain factors place some patients at even higher risk. Among these factors are:

Side Effects

In clinical trials, Arthrotec was generally well-tolerated. The most common side effects were:

Side effects were usually mild, lasting less than one week. Arthrotec is notably contraindicated in pregnant women or women who may become pregnant. Misoprostol has properties that may cause abortion, premature birth, or birth defects.

Related Resources

_{Sources: FDA Clears Arthrotec For Arthritis Therapy, Doctor's Guide, P/S/L Consulting Group, Inc.; Arthrotec, by drdoc on-line}