Rheumatoid arthritis is less common in men than women. It has been suggested that sex hormones play some role in the development of rheumatoid arthritis. Men with rheumatoid arthritis tend to have lower levels of testosterone than men without the disease. Researchers conducted a study to determine if hormonal changes precede the development of rheumatoid arthritis.
According to results published online April 3, 2013 in the Annals of the Rheumatic Diseases, lower levels of testosterone were associated with the subsequent development of seronegative rheumatoid arthritis. Seronegative is a reference to being negative for rheumatoid factor. The finding offers more evidence that hormonal changes precede the onset of rheumatoid arthritis.
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