Acute kidney injury is a major problem and is often related to adverse drug reactions. It is known that certain individual classes of drugs are associated with potential kidney injury, such as antiretroviral drugs, aminoglycoside antibiotics and nonsteroidal anti-inflammatory drugs (NSAIDs). Less is known about drug interactions and acute kidney injury.
NSAIDs are commonly prescribed to treat arthritis. According to the British Medical Journal, researchers studied the effects of a double therapy, with patients taking either diuretics, angiotensin converting enzyme inhibitors, or angiotensin receptor blockers, with NSAIDS. They also assessed the effect of taking three -- two of the aforementioned hypertension drugs plus NSAIDs. Researchers concluded that the triple therapy consisting of diuretics, plus angiotensin converting enzyme inhibitors or angiotensin receptor blockers, along with NSAIDs increased the risk of acute kidney injury by 31%. The highest risk seems to occur within the first 30 days of triple therapy.
Photo by Doug Cannell (iStockphoto)