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Carol Eustice

NSAIDs Plus Two Blood Pressure Medications Can Affect Kidneys

By January 14, 2013

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Acute kidney injury is a major problem and is often related to adverse drug reactions. It is known that certain individual classes of drugs are associated with potential kidney injury, such as antiretroviral drugs, aminoglycoside antibiotics and nonsteroidal anti-inflammatory drugs (NSAIDs). Less is known about drug interactions and acute kidney injury.

NSAIDs are commonly prescribed to treat arthritis. According to the British Medical Journal, researchers studied the effects of a double therapy, with patients taking either diuretics, angiotensin converting enzyme inhibitors, or angiotensin receptor blockers, with NSAIDS. They also assessed the effect of taking three -- two of the aforementioned hypertension drugs plus NSAIDs. Researchers concluded that the triple therapy consisting of diuretics, plus angiotensin converting enzyme inhibitors or angiotensin receptor blockers, along with NSAIDs increased the risk of acute kidney injury by 31%. The highest risk seems to occur within the first 30 days of triple therapy.

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January 16, 2013 at 11:32 am
(1) Sallie says:

Wow! I never expected that. I really wonder what to take anymore. I have spinal problems and take an Nsaid everyday, a prescription. No matter what you do it seems you’re doomed. I do read your newsletter every week because you are always informing me of the latest studies. Thank you.

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