Adults with refractory chronic gout who were treated bi-weekly with Krystexxa (pegloticase) experienced "statistically significant and clinically meaningful improvements" in health-related quality of life (HRQOL), pain, and physical function. Study results were published in the July 2012 issue of the Journal of Rheumatology.
The conclusions were drawn from a pooled analysis of two Phase III studies that included patients treated with 8 mg. Krystexxa every 2 weeks or 4 weeks compared to placebo. Patients receiving monthly Krystexxa also improved in health-related quality of life but not as significantly as those receiving the drug every two weeks.
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