FDA Warns Proton Pump Inhibitors Can Lower Magnesium Levels

Proton pump inhibitors, also known as PPIs, include drugs such as Nexium, Prevacid, Protonix, and Prilosec. According to the FDA, proton pump inhibitors may cause low magnesium levels if taken for long periods of time. Low serum magnesium levels can cause serious adverse events including muscle spasm, irregular heartbeat, and seizures. Not all patients will experience these symptoms though. Magnesium supplements are typically used to treat low magnesium levels. But in about 25% of cases reviewed, magnesium supplements alone did not sufficiently raise low magnesium levels and the proton pump inhibitor was discontinued.

Proton pump inhibitors reduce the risk of ulcers by decreasing the amount of acid in the stomach. That's why some arthritis patients who take NSAIDs (nonsteroidal anti-inflammatory drugs) also take a proton pump inhibitor. NSAIDs, such as ibuprofen, naproxen, aspirin and Celebrex, when taken regularly or at high doses raise the risk of gastric and duodenal ulcers. If you take a proton pump inhibitor, talk to your doctor about checking your magnesium level. Read more from the FDA about longterm use of proton pump inhibitors and low magnesium.

Related Resources:

• Nexium Reduces Risk of Ulcers for NSAID Users
• Vimovo Approved to Treat Arthritis
• Proton Pump Inhibitors Increase Risk of Hip Fracture
• 9 Ways to Reduce Your Risk of Bleeding Ulcers from NSAID Use

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