Uloric works by reducing levels of uric acid. About one-third of the uric acid in our bodies comes from the food we eat -- the rest we produce ourselves through ordinary metabolism. When levels of uric acid are elevated in the blood, it can lead to the formation of needle-like crystals that can become deposited in the joints causing gout -- an intensely painful condition.
Early on there were concerns that clinical trials of Uloric showed a higher risk of death and heart problems associated with the drug. But a larger study found no difference in heart risk when Uloric was compared to allopurinol. Uloric is said to work better for patients who have kidney problems too. Many gout patients also have kidney disease. While the FDA does not have to follow the recommendation of the committee, it typically does.
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