Three Genes Linked to Increased Risk of Gout

Gout is a painful inflammation of the joints which can develop along with a build-up of uric acid in the blood, known as hyperuricemia. There are known risk factors for gout, including a diet high in purine-rich foods, obesity, alcohol consumption, taking certain medications, and a genetic predisposition for the disease.

Researchers from the United States and the Netherlands have identified mutations in 3 genes that are associated with high levels of uric acid in the blood. According to study results published in the October 4, 2008 issue of The Lancet, researchers evaluated 500,000 genetic variations in more than 20,000 people who were enrolled in three large studies looking at cardiovascular risk factors. They confirmed that two genes increased the risk of gout, and another was likely associated with increased gout risk. The genes are involved with urate transport in the kidney.

Based on what researchers called "genetic risk scores", the 3 genes combined were associated with up to a 40-fold increased risk of developing gout. It is believed that this could identify people at high risk of developing gout long before symptoms are observed. It may also help determine the best treatment for patients with hyperuricemia who have yet to show gout symptoms.

Related Resources:

• Gout Screening Quiz
• Gout Risk Factors
• Gout - Foods to Eat
• Test Your Knowledge - Gout
• Gout - 10 Things You Should Know

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