Study results published in the April 2007 Annals of the Rheumatic Diseases concluded that high cardiovascular risk patients taking ibuprofen and aspirin combined are nine times more likely to suffer a heart attack because ibuprofen interferes with the blood thinning properties of aspirin in those high risk patients. In osteoarthritis patients with high cardiovascular risk who were not taking low-dose aspirin, the rate of heart attacks was:
- higher for patients on lumiracoxib than it was for patients on naproxen.
- no higher for patients on ibuprofen versus lumiracoxib.
The interference of ibuprofen on aspirin's effects in high risk cardiovascular patients is an interaction with potentially serious consequences.
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