- 5,337 men had hyperuricemia at beginning of the study.
- 1,123 men developed gouty arthritis during the study.
- There was no statistical difference between groups over cholesterol levels, use of aspirin, family history of heart attack, or diabetes mellitus.
- The gout group was found to more likely use diuretics and alcohol, and have elevated blood pressure, age, blood glucose, and body mass index.
- More smokers were found in the group without gout.
During the study, 1,108 heart attacks occurred in the gout group (10.5 percent) and 990 heart attacks occurred in the group without gout (8.43 percent). 246 of the 1,108 heart attacks were fatal. The connection between gout and risk of heart attack was also obvious among those who did not use alcohol, diuretics, or aspirin as well as those who did not have metabolic syndrome, diabetes mellitus, or obesity. This was the first study, among men with no prior history of coronary artery disease, that revealed gout is a significant risk factor for heart attack.
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